Diabetes With Obesity Ups Liver Transplant Morbidity

However, these concomitant risk factors do not appear to affect recipient survival

WEDNESDAY, Jan. 29, 2014 (HealthDay News) -- Morbidity is increased in the early postoperative phase following liver transplant for patients who have obesity with diabetes mellitus, according to research published online Jan. 7 in Liver Transplantation.

In an effort to assess the influence of pre-transplant risk variables on postoperative morbidity and survival, Anna J. Dare, M.B.Ch.B., of the University of Auckland in New Zealand, and colleagues analyzed data from a cohort of 202 consecutive patients receiving a liver transplant. Variables included coronary artery disease, diabetes mellitus, hypertension, and obesity.

The researchers found a high level of agreement (86 percent) between body mass index and percentage of body fat for the classification of patients as obese or non-obese. Independent factors that increased risk for a higher postoperative event rate included diabetes mellitus (counts ratio [CR], 1.4; P < 0.001) and obesity (CR, 1.03; P < 0.001). The strongest predictor of increased risk for higher postoperative event rate (CR, 1.75; P < 0.001) and longer hospital stay (5.81 days; P < 0.01) was obesity with concomitant diabetes mellitus. No effect on survival (30-day, one-year, or five-year) was observed for independent metabolic risk factors.

"Early post-liver transplantation morbidity is highest in patients with concomitant obesity and diabetes mellitus, though these factors do not appear to influence recipient survival," the authors write.

Abstract (http://onlinelibrary.wiley.com/doi/10.1002/lt.23818/abstract )Full Text (subscription or payment may be required) (http://onlinelibrary.wiley.com/doi/10.1002/lt.23818/pdf )