1 Janetzky K, Morreale AP. Probable interaction between warfarin and ginseng. Am J Health Syst Pharm. 1997;54:692-693.
2 Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q 10 during treatment with HMG-CoA reductase inhibitors. Mol Aspects Med. 1997;18(suppl):S137-S144.
3 Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ 10 -lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study. J Clin Pharmacol. 1993;33:226-229.
4 Combs AB, Porter TH, Folkers K. Anticoagulant activity of a naphtoquinone analog of vitamin K and an inhibitor of coenzyme Q 10 -enzyme systems. Res Commun Chem Pathol Pharmacol. 1976;13:109-114.
5 Spigset O. Reduced effect of warfarin caused by ubidecarenone [letter]. Lancet. 1994;344:1372-1373.
6 Lo ACT, Chan K, Yeung JHK, et al. The effects of Danshen (Salvia miltorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats. Eur J Drug Metab Pharmacokinet. 1992;17:257-262.
7 Brinker F. Herb Contraindications and Drug Interactions: With Appendices Addressing Specific Conditions and Medicines. 2nd ed. Sandy, OR: Eclectic Medical Publications; 1998.
8 Chan TY. Interaction between warfarin and danshen (Salvia miltiorrhiza) . Ann Pharmacother. 2001;35:501-504.
9 Shaw D, Leon C, Kolev S, et al. Traditional remedies and food supplements. A 5-year toxicological study (1991-1995). Drug Saf. 1997;17:342-356.
10 Page RL II, Lawrence JD. Potentiation of warfarin by dong quai. Pharmacotherapy. 1999;19:870-876.
11 Heptinstall S, Groenewegen WA, Spangenberg P, et al. Extracts of feverfew may inhibit platelet behavior via neutralization of sulphydryl groups. J Pharm Pharmacol. 1987;39:459-465.
12 Makheja AN, Bailey JM. The active principle in feverfew [letter]. Lancet. 1981;2:1054.
13 Sumner H, Salan U, Knight DW, et al. Inhibition of 5-lipoxygenase and cyclo-oxygenase in leukocytes by feverfew. Involvement of sesquiterpene lactones and other components. Biochem Pharmacol. 1992;43:2313-2320.
14 Groenewegen WA, Heptinstall S. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. J Pharm Pharmacol. 1990;42:553-557.
15 Biggs MJ, Johnson ES, Persaud NP, et al. Platelet aggregation in patients using feverfew for migraine [letter]. Lancet. 1982;2:776.
16 Gadkari JV, Joshi VD. Effect of ingestion of raw garlic on serum cholesterol level, clotting time and fibrinolytic activity in normal subjects. J Postgrad Med. 1991;37:128-131.
17 Burnham BE. Garlic as a possible risk for postoperative bleeding. Plast Reconstr Surg. 1995;95:213.
18 Kiesewetter H, Jung F, Jung EM, et al. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischemic attack. Eur J Clin Pharmacol. 1993;45:333-336.
19 [No authors listed]. The effect of essential oil of garlic on hyperlipemia and platelet aggregation—an analysis of 308 cases. Cooperative Group for Essential Oil of Garlic. J Tradit Chin Med. 1986;6:117-120.
20 Bordia A. Effect of garlic on human platelet aggregation in vitro. Atherosclerosis. 1978;30:355-360.
21 Rose KD, Croissant PD, Parliament CF, et al. Spontaneous spinal epidural hematoma with associated platelet dysfunction from excessive garlic ingestion: a case report. Neurosurgery. 1990;26:880-882.
22 Sunter WH. Warfarin and garlic. Pharm J. 1991;246:722.
23 Backon J. Ginger: inhibition of thromboxane synthetase and stimulation of prostacyclin: relevance for medicine and psychiatry. Med Hypotheses. 1986;20:271-278.
24 Srivastava KC. Aqueous extracts of onion, garlic and ginger inhibit platelet aggregation and alter arachidonic acid metabolism. Biomed Biochim Acta. 1984;43:S335-S346.
25 Bordia A, Verma SK, Srivastava KC. Effect of ginger ( Zingiber officinale Rosc.) and fenugreek ( Trigonella foenumgraecum L. ) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 1997;56:379-384.
26 Janssen PL, Meyboom S, van Staveren WA, et al. Consumption of ginger (Zingiber officinale roscoe) does not affect ex vivo platelet thromboxane production in humans. Eur J Clin Nutr. 1996;50:772-774.
27 Lumb AB. Effect of dried ginger on human platelet function. Thromb Haemost. 1994;71:110-111.
28 Chung KF, Dent G, McCusker M, et al. Effect of a ginkgolide mixture (BN 52063) in antagonising skin and platelet responses to platelet activating factor in man. Lancet. 1987;1:248-251.
29 Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract [letter]. N Engl J Med. 1997;336:1108.
30 Rowin J, Lewis SL. Spontaneous bilateral subdural hematomas with chronic Ginkgo biloba ingestion. Neurology. 1996;46:1775-1776.
31 Vale S. Subarachnoid hemorrhage associated with Ginkgo biloba [letter]. Lancet. 1998;352:36.
32 Matthews MK Jr. Association of Ginkgo biloba with intracerebral hemorrhage. Neurology. 1998;50:1933-1934.
33 Taylor JR, Wilt VM. Probable antagonism of warfarin by green tea. Ann Pharmacother. 1999;33:426-428.
34 Monostory K, Vereczkey L, Levai F, et al. Ipriflavone as an inhibitor of human cytochrome P450 enzymes. Br J Pharmacol. 1998;123:605-610.
35 Shaw D, Leon C, Kolev S, et al. Traditional remedies and food supplements. A 5-year toxicological study (1991-1995). Drug Saf. 1997;17:342-356.
36 Arruzazabala ML, Mas R, Molina V, et al. Effect of policosanol on platelet aggregation in type II hypercholesterolemic patients. Int J Tissue React. 1998;20:119-124.
37 Arruzazabala ML, Mas R, Molina V, et al. Effect of policosanol on platelet aggregation in type II hypercholesterolemic patients. Int J Tissue React. 1998;20:119-124.
38 Arruzazabala ML, Valdes S, Mas R, et al. Effect of policosanol successive dose increases on platelet aggregation in healthy volunteers. Pharmacol Res. 1996;34:181-185.
39 Arruzazabala ML, Valdes S, Mas R, et al. Comparative study of policosanol, aspirin and the combination therapy policosanol-aspirin on platelet aggregation in healthy volunteers. Pharmacol Res. 1997;36:293-297.
40 Maurer A. Interaction of St. John's wort extract with phenprocoumon. Eur J Clin Pharmacol. 1999;55:A22.
41 Jobst KA, McIntyre M, St. George D, et al. Safety of St. John's wort (Hypericum perforatum) . Lancet. 2000:355:575.
42 Johne A, Brockmuller J, Bauer S, et al. Pharmacokinetic interaction of digoxin with an herbal extract from St. John's wort (Hypericum perforatum) . Clin Pharmacol Ther. 1999;66:338-345.
43 Yue QY, Bergquist C, Gerden B. Safety of St. John's wort [letter]. Lancet. 2000;355:576-577.
44 Hitzenberger G, Sommer W, Grandt R. Influence of vinpocetine on warfarin-induced inhibition of coagulation. Int J Clin Pharmacol Ther Toxicol. 1990;28:323-328.
45 Harris JE. Interaction of dietary factors with oral anticoagulants: review and applications. J Am Dietet Assoc. 1995;95:580-584.
46 Harris JE. Interaction of dietary factors with oral anticoagulants: review and applications. J Am Dietet Assoc. 1995;95:580-584.
47 Schrogie JJ. Letter: Coagulopathy and fat-soluble vitamins. JAMA. 1975;232:19.
48 Rosenthal G. Interaction of ascorbic acid and warfarin [letter]. JAMA. 1971;215:1671.
49 Smith EC, Skalski RJ, Johnson GC, et al. Interaction of ascorbic acid and warfarin [letter]. JAMA. 1972;221:1166.
50 White JG, Rao GH, Gerrard JM. Effects of nitroblue tetrazolium and vitamin E on platelet ultrastructure, aggregation, and secretion. Am J Pathol. 1977;88:387-402.
51 Kim JM, White RH. Effect of vitamin E on the anticoagulant response to warfarin. Am J Cardiol. 1996;77:545-546.
52 Corrigan J, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA. 1974;230:1300-1301.
53 Schrogie JJ. Letter: Coagulopathy and fat-soluble vitamins. JAMA. 1975;232:19.
54 Pedersen FM, Hamberg O, Hess K, et al. The effect of dietary vitamin K on warfarin-induced anticoagulation. J Intern Med. 1991;229:517-520.
55 Chow WH, Chow TC, Tse TM, et al. Anticoagulation instability with life-threatening complication after dietary modification. Postgrad Med J. 1990;66:855-857.
56 Weinrobe MC, Montgomery B. Acquired bleeding diathesis in a patient taking PC-SPES [letter]. N Engl J Med. 2001;345:1213-1214.
57 Lambert JP, Cormier A. Potential interaction between warfarin and boldo-fenugreek. Pharmacotherapy. 2001;21:509-512.
58 Su C, Shiao M, Wang C. Potentiation of ganodermic acid S on prostaglandin E(1)-induced cyclic AMP elevation in human platelets. Thromb Res. 2000;99:135-145.
59 Engelsen J, Nielsen JD, Winther K. Effect of coenzyme Q10 and Ginkgo biloba on warfarin dosage in stable, long-term warfarin treated outpatients. A randomised, double blind, placebo-crossover trial. Thromb Haemost. 2002;87:1075-1076.
60 Kiss B, Karpati E. Mechanism of action of vinpocetine [in Hungarian; English abstract]. Acta Pharm Hung. 1996;66:213-214.
61 Sovak M, Seligson AL, Konas M, et al. PC-SPES in prostate cancer: an herbal mixture currently containing warfarin and previously diethylstilbestrol and indomethacin. Presented at: 93rd Annual Meeting of the American Association for Cancer Research; April 6-10, 2002; San Francisco, CA.
62 AbdelFattah W, Hammad T. Chondroitin sulfate and glucosamine: A review of their safety profile. JANA 2001;3:16-23.
63 Yuan CS, Wei G, Dey L, et al. American ginseng reduces warfarin's effect in healthy patients. Ann Intern Med. 2004;141:23-27.
64 Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2004;57:592-599.
65 Committee on Safety of Medicines. Possible interaction between warfarin and cranberry juice. Current Problems in Pharmacovigilance. 2003;29:8.
66 Kohler S, Funk P, Kieser M. Influence of a 7-day treatment with Ginkgo biloba special extract EGb 761 on bleeding time and coagulation: a randomized, placebo-controlled, double-blind study in healthy volunteers. Blood Coagul Fibrinolysis. 2004;15:303-309.
67 Kudolo GB, Dorsey S, Blodgett J. Effect of the ingestion of Ginkgo biloba extract on platelet aggregation and urinary prostanoid excretion in healthy and Type 2 diabetic subjects. Thromb Res. 2002;108:151-160.
68 Bal Dit Sollier C, Caplain H, Drouet L. No alteration in platelet function or coagulation induced by EGb761 in a controlled study. Clin Lab Haematol. 2003;25:251-253.
69 Hauser D, Gayowski T, Singh N. Bleeding complications precipitated by unrecognized Gingko biloba use after liver transplantation. Transpl Int. 2002;15:377-379. Epub 2002 Jun 19.
70 Fong KC, Kinnear PE. Retrobulbar haemorrhage associated with chronic Gingko biloba ingestion. Postgrad Med J. 2003;79:531-532.
71 Cambria-Kiely JA. Effect of soy milk on warfarin efficacy. Ann Pharmacother. 2002;36:1893-1896.
72 Jiang X, Williams KM, Liauw WS, et al. Effect of St John's wort and ginseng on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2004;57:592-599.
73 Beatty SJ, Mehta BH, Rodis JL. Decreased warfarin effect after initiation of high-protein, low-carbohydrate diets. Ann Pharmacother. 2005;39:744-747.
74 Segal R, Pilote L. Warfarin interaction with Matricaria chamomilla. CMAJ. 2006;174:1281-1282.
75 Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: In vitro and clinical studies. Clin Pharmacol Ther. 2006;79:125-133.
76 Kudolo GB, Wang W, Barrientos J, et al. The ingestion of gingko biloba extract (EGb 761) inhibits arachidonic acid-mediated platelet aggregation and thromboxane B 2 production in healthy volunteers. J Herb Pharmacother. 2005;4:13-26.
77 Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2005;59:425-432.
78 Buckley MS, Goff AD, Knapp WE, et al. Fish oil interaction with warfarin. Ann Pharmacother. 2004;38:50-52.
79 Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol. 2005;59:425-432.
80 Li Z, Seeram NP, Carpenter CL, et al. Cranberry does not affect prothrombin time in male subjects on warfarin. J Am Diet Assoc. 2006;106:2057-2061.
81 Pham DQ, Pham AQ. Interaction potential between cranberry juice and warfarin. Am J Health Syst Pharm. 2007;64:490-494.
82 Welch JM, Forster K. Probable elevation in international normalized ratio from cranberry juice. J Pharm Technol. 2007;23:104-107.
83 Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy. 2006;26:583-586.
84 Rombouts EK, Rosendaal FR, van der Meer FJ. Daily vitamin K supplementation improves anticoagulant stability. J Thromb Haemost. 2007 Jul 31. [Epub ahead of print]
85 Lee SH, Ahn YM, Ahn SY, et al. Interaction between warfarin and Panax ginseng in ischemic stroke patients. J Altern Complement Med. 2008 Jul 20.
- Reviewer: EBSCO CAM Review Board
- Review Date: 07/2012 -
- Update Date: 07/25/2012 -