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AAP: Rise Seen in Pediatric MRSA Musculoskeletal Infections

AAP: Rise Seen in Pediatric MRSA Musculoskeletal Infections

Infections tied to longer inpatient stays, more surgical interventions, increased complication risk

TUESDAY, Oct. 29 (HealthDay News) -- Over the past decade, pediatric methicillin-resistant Staphylococcus aureus (MRSA) musculoskeletal infections have increased in frequency, according to a study presented at the annual meeting of the American Academy of Pediatrics, held from Oct. 26 to 29 in Orlando, Fla.

Eric Sarkissian, from the Children's Hospital of Philadelphia, and colleagues studied a consecutive series of patients presenting with culture-positive S. aureus osteomyelitis, septic arthritis, or both from January 2001 through June 2010, excluding postoperative and chronic infections.

The researchers identified 148 cases of acute musculoskeletal S. aureus infection (111 methicillin-sensitive Staphylococcus aureus [MSSA] and 37 MRSA). The proportion of musculoskeletal infections caused by MRSA increased from the start of the decade to its end (from 9 to 29 percent). There was a longer average duration of hospitalization in the MRSA group compared to the MSSA group (13 versus eight days). Multiple surgical procedures were more frequently performed in MRSA versus MSSA patients (38 versus 15 percent). In MRSA patients, infection-related complications, including deep venous thrombosis, septic emboli, septic shock, recurrent infection, and/or avascular necrosis, were more common than in MSSA patients (22 versus 6 percent).

"Our findings support prior concern about the increased virulence of MRSA compared to MSSA infections," Sarkissian said in a statement.

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