No difference in bone mineral content at age 9 to 10 years with sufficient, deficient maternal 25(OH)D
TUESDAY, March 19 (HealthDay News) -- There is no association between maternal 25-hydroxyvitamin D (25[OH]D) concentration and bone mineral content (BMC) in offspring at age 9 to 10 years, according to a study published online March 19 in The Lancet.
Debbie A. Lawlor, Ph.D., from the University of Bristol in the United Kingdom, and colleagues examined the correlation between maternal vitamin D status in pregnancy and BMC in offspring using data from 3,960 mother-and-singleton-offspring pairs. Measurements of 25(OH)D concentration were recorded in pregnancy and total body less head (TBLH) and spinal BMC were assessed using dual-energy X-ray absorptiometry in offspring at a mean age of 9.9 years.
During pregnancy, the researchers found that 77 percent of mothers had sufficient, 28 percent had insufficient, and 6 percent had deficient 25(OH)D concentrations. There was no difference in TBLH or spinal BMC for offspring of mothers with insufficient or deficient 25(OH)D concentrations compared with offspring of mothers with sufficient 25(OH)D concentrations. There was no correlation with offspring BMC in any trimester.
"We believe, therefore, that there is no strong evidence that pregnant women should receive vitamin D supplementation to prevent low BMC in their offspring, although we cannot comment on other possible effects of vitamin D in pregnant women," the authors write. "Our results should not be interpreted as suggesting that individual 25(OH)D concentrations are not an important determinant of bone health."
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